Benzamide, 2-[[5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]oxy]-N-methyl-
SBI-0206965
CAS: 1884220-36-3
Molecular Formula: C21H21BrN4O5
Benzamide, 2-[[5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]oxy]-N-methyl- - Names and Identifiers
Benzamide, 2-[[5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]oxy]-N-methyl- - Physico-chemical Properties
| Molecular Formula | C21H21BrN4O5 |
| Molar Mass | 489.32 |
| Density | 1.434±0.06 g/cm3(Predicted) |
| Melting Point | 170 - 172°C |
| Solubility | 10 mM in DMSO |
| Appearance | powder |
| Color | white to beige |
| pKa | 14.80±0.46(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| In vitro study | In HEK293T transfected with WT or KI Myc-labeled ULK1 and WT Vps34, SBI-0206965 inhibited Ser249 phosphorylation and Beclin1 Ser15 phosphorylation of overexpressing vps34. In A549 cells, SBI-0206965 inhibited mTOR inhibition-induced autophagy and prevented ulk1-dependent cell survival in WT MEFs. In addition, SBI-0206965 also enhances mTOR inhibition to induce cancer cell death. |
Benzamide, 2-[[5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]oxy]-N-methyl- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.044 ml | 10.218 ml | 20.437 ml |
| 5 mM | 0.409 ml | 2.044 ml | 4.087 ml |
| 10 mM | 0.204 ml | 1.022 ml | 2.044 ml |
| 5 mM | 0.041 ml | 0.204 ml | 0.409 ml |
Last Update：2024-01-02 23:10:35
Benzamide, 2-[[5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]oxy]-N-methyl- - Reference Information
| biological activity | SBI-0206965 is a highly selective autophagocytic kinase ULK1 inhibitor with IC50 of 108 nM, which is 7 times more selective than ULK2. SBI-0206965 can inhibit autophagy in human glioblastoma and lung cancer cells and enhance apoptosis. |
| target | TargetValue ULK1 (cell-free say) 108 nM ULK2 (cell-free say) 711 nM |
| Target | Value |
| ULK1 (Cell-free assay) | 108 nM |
| ULK2 (Cell-free assay) | 711 nM |
| in vitro study | In the HEK293T transfected with WT or KI Myc-labeled ULK1 and WT Vps34, Ser249 phosphorylation and Beclin1 Ser15 phosphorylation were SBI-0206965 inhibited. In A549 cells, SBI-0206965 inhibited autophagy induced by mTOR inhibition and prevented ULK1-dependent cell survival in WT MEFs. In addition, SBI-0206965 will also enhance mTOR inhibition to induce cancer cell death. |
Last Update：2024-04-09 21:50:46
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Spot supply
Product Name: SBI-0206965 Visit Supplier Webpage Request for quotationCAS: 1884220-36-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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